Acute toxicity and articaine d-s forte cumulation in different ways of administration

The paper presents results of a study of acute toxicity and cumulative properties of articaine at different routes of administration in mice. The experiment found that the maximum tolerated dose of articaine D-S Forte for mice with intraperitoneal administration is 240mg / kg, LD16 = 253.24; average lethal dose LD50 = 266,67 ± 2,76, absolutely lethal dose – 290mg / kg, and the coefficient of cumulation is Cc = 5.48. The maximum tolerated dose when administered intramuscularly for mice is 150 mg / kg LD16 = 203 mg /kg LD50 = 255 ± 21,71mg / kg and LD100 – 400mg / kg.

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Influence of hypertensive crisis on evaluation of quality of life of patients with arterial hypertension

In accordance with the concept of the WHO one of the main objectives of patient treatment is the reduction or elimination of disease symptoms, control over them and over the factors of the risk. However, this goal cannot be fully achieved if the patient sense of well-being – physical, mental and socialis not taken into account. The dynamics of clinical indicators during the process of treatment is less important for a patient than the impact of the disease on his functioning in the society, in the family and his sense of life satisfaction. The life quality criteria are used for evaluation of these health components. The quality of life as an integral multifactorial indicator allows estimating individual importance of different components for the certain patient, including the economic, sociological, psychological and medical aspects.
The life quality analysis conducted on the non-specific questionnaire SF-36 showed that most of the patients feel themselves completely healthy after having hypertensive crisis. The presence of severe symptoms of hypertensive crisis significantly lowers the quality of life, but only for the period of the crisis. The hypertensive crisis, roughly reducing the working ability, makes people draw their attention to their own health. After relieving the symptoms of the disease only older patients have lower indicators of the quality of life caused by longer period of the disease as well as the presence of comorbidity. As our survey of the quality of life showed the majority of patients admitted the relief of hypertensive crisis symptoms as a recovery that was evidenced by the presence of 100-point assessment of the state of their health before their discharge on the scale of physical functioning, role functioning connected with both health and emotions, and the intensity of pain. Only patients with a long clinical record and comorbidity evaluate the results of the treatment and the prognosis of their health state for the future more modestly.

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Features of life and medical activity of intensivists

The article presents data of questionnaire of intensivists, other physicians (internists), middle and junior medical staff of multidisciplinary hospital. Our findings revealed a number of features, some of them linked to incidence of such bad habits as smoking and the alcohol abuse, the others – with food and physical activity. It is shown that on the basis of personal assessment the food habits of intensivists do not correspond to the principles of a healthy diet, recommended by the World Health Organization and physical activities are related to household activities and work in their spare time in the garden area, while recreational exercises and tempering of the body are regularly performed only by a small part of the doctors. The article also assessed the medical activities of physicians compared to nurses working in intensive care units of general hospital, and shows that indicators of physical operational readiness of doctors are worse than of nurses of intensive care units.

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Investigation of molecular ultrastructure of biological membranes of lymphocytes in case of BLV-infection

Viral leukemia of cows is a chronic infectious disease characterized by neoplasia of hematopoietic tissue. The agent of disease BLV is found in infected lymphocytes as a provirus. The infected lymphocyte is not destroyed in the susceptible organism. The goal of our research is comparison of the structural and functional state of the cytoskeleton of lymphocytes of healthy and BLV-infected cattle using the method of atomic force microscopy. It was found out that the surface of healthy lymphocytes is smoother, their average volume is 21.5 % bigger and Yung’s module is 37% higher than those of the infected cells. So, membranes of lymphocytes of BLV-infected cattle are characterized by increased rigidity with less elasticity.

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Public healthcare: study of the hierarchical interaction of the concerned sectors

Objective: To study the hierarchical interaction of sectors interested in the healthcare of population. Materials and methods. Anonymous survey among healthcare organizers. Results. The comparative assessment of the linkages between the sectors interested in the healthcare of population was held. Conclusion. These results complement the understanding of the functioning of system of inter-sectoral cooperation in public health and can be useful in proving the directions of its optimization.

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Availability of medical laboratory tests for doctors of the samara region

This paper provides information about the availability of referral to the laboratory tests for different groups of doctors of the Samara Region. The work took into account the opinion of practitioners with higher medical education. It was found that the prevailing group of doctors, regardless of age, sex, qualification category, professional experience, has insignificant restrictions (low availability for some rare tests only). The difference is observed for doctors with different geography of work: doctors in rural areas have more obstacles than the doctors from the cities. It is revealed that doctors who use laboratory studies in their practice most have practically no limitations in the laboratory tests, or they are few in number, whereas other groups of doctors have a similar picture of the limitation in the appointment of tests.

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Evaluation of psychoneurological problems of people with gastroenterological pathology

There was conducted an evaluation of psychoneurological problems of people with a gastroenterological profile. 49 persons were investigated: 25 men and 24 women on inpatient treatment. The average age of men was 47 years old and the average age of women was 49 years old. In our work, a new method of screening the functional state of the organism via the medical expert complex CME SWISS AG (Slovakia) was applied. Also, a computerized program of evaluation of the current psychological state CMS (Russia) was used as well as widely known psychophysiological methods applied via the NS-PsychoTest complex (Russia). Eating behavior, social status, subjective states, etc. were taken into account. Results of the research based on the whole complex of used methods showed that the majority of patients of the investigated group are characterized by common psychoneurological issues: fear, suppressed nervousness, low selfesteem, etc. There is very often a state of chronic stress and an extremely low level of resources for adaptation. Significance of the psychic factor for the efficiency of the conducted therapy was also noted.

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The issue of national cultural and religious preferences of the production and use of medicines

The article raises the question of the relationship between the source of origin of the feedstock for the production of medicines and preferences or restrictions in patients in their application based on their ethnocultural and religious traditions. This is a relatively independent, relevant and practically important topic for consideration in the framework of social pharmacy, studying medicines in a broader perspective (political, ethical, social, etc. aspects). In accordance with this approach, as well as in the context of the implementation of the “Agreement on Cooperation between the Ministry of Health of Russia and Russian Orthodox Church” the Federal Law “On biomedical cell products” was discussed. Based on the review of the Law and the “Social Concept of the Russian Orthodox Church” the conclusion was made about the moral acceptability of the Orthodox consciousness of biomedical cellular products usage, the raw material for which are the cells, tissues and organs taken from living and dead people (donors).

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Experimental evaluation of efficiency of application of physiological solutions for prevention of late effects of acute intoxication with carbon oxide

Acute intoxications with carbon oxide are one of the current toxicological problems. Among the reasons of fatal outcomes in case of acute intoxications for the last 10 years, intoxications with carbon oxide make up about 25 %, following intoxications with alcohol and its substitutes. There is a real danger that together with civil citizens military men can be affected both in battle conditions and in daily military activities. It is acknowledged throughout the world that late effects for people who suffered from the acute CO intoxication can develop different stable variations of the nervous system functioning. The problem of late effects of encephalopathy prevention after acute intoxications with carbon oxide remains unresolved. There is a proven fact that a true highly efficient antidote for intoxications with carbon oxide is oxygen. There is still being performed a search of a possibility to apply solutions with enhanced concentration of ox-ygen in normal conditions for prevention and treatment of acute intoxications with carbon oxide. As a result, there arises a question of efficiency of applying solutions of another form of oxygen for the same purpose – ozone. In our work, there was conducted an experimental evaluation of late effects of peroral application of ozonized physiological solutions for prevention of memory and learning disorders in rats after an acute intoxication with carbon oxide. The results were supported with a morphological investigation of the rats’ brain.

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