Composition of the carbohydrate component in the platelets glycoprotein receptors in patients underwent surgeries on damaged spleen in the long-term postoperative period

The goal of the study was to analyze the changes in the carbohydrate part of the platelets glycoprotein receptors in patients underwent splenectomy, autolientransplantation and conservative surgeries in the longterm postoperative period. Materials and methods. Changes in the carbohydrate part of the platelets glycoprotein receptors were
analyzed in 126 patients underwent surgery on the damaged spleen during more than one year. Among this group, 26 patients were examined using laser technology after conservative surgeries, 46 patients had autolientransplantations and 54 underwent splenectomy. The control group consisted of 50 relatively healthy people of the same age and sex. Platelet aggregation was assessed by standard turbidimetric analysis. Plant lectins were used as the inducers of platelet aggregation. The analysis revealed that the parameters of the platelets membrane glycoprotein receptors do not correlate with the changes in the platelet membrane glycoprotein receptors in patients underwent conservative surgeries on damaged spleen in the long-term postoperative period. Autolientransplantations patients showed no changes in b-D-galactose and N-glycans platelets membrane glycoprotein receptors. At the same time, the study showed increased aggregation activity for platelets bearing N-acetyl-D-glucosamine and N-acetylneuraminic (sialic) acid glycoprotein receptors. In the splenectomy patients the investigators registered increased aggregation activity of the platelets with b-D-galactose, N-acetyl-D-glucosamine and N-acetylneuraminic (sialic) acid glycoprotein receptors and increased platelets aggregation activity due to increased number of mannose glycoprotein receptors.

Read more...