There was carried out a complex treatment of 71 patients of C6 clinical class according to CEAP. The age group is 62.3±7.1 years old. The anamnesis of trophic ulcers is 6.8±1.7 years. There was performed phlebectomy (n=71) togeth-er with free autodermoplasty with a split perforated graft. Patients of group І (n=35) received a layer-by-layer der-molipectomy. Patients of group ІІ (n=36) did not receive shavetherapy. Statistical differences between groups were not detected. Evaluation of late results of the treatment was done within the terms of 1 up to 12 months. 27 patients (77.1%) of group I showed full autodermoplasty engraftment, in group II there were 7 patients (19.4 %) (χ2=23.674; р=0.001). Epithelization of partial graft necrosis (24.3±4.8 cm2) was detected for 8 patients (22.9 %) of group I on the 42.4±4.5 day. In group II, partial necrosis (67.1±10.5 cm2) was detected for 29 patients (80.6 %), absence of full epithelization was detected for 3 patients (8.3 %). Layer-by-layer dermolipectomy together with autodermoplasty with a perforated graft is an effective method of treatment of persistent refractory venous trophic ulcers.