Experimental evaluation of efficiency of application of physiological solutions for prevention of late effects of acute intoxication with carbon oxide

Acute intoxications with carbon oxide are one of the current toxicological problems. Among the reasons of fatal outcomes in case of acute intoxications for the last 10 years, intoxications with carbon oxide make up about 25 %, following intoxications with alcohol and its substitutes. There is a real danger that together with civil citizens military men can be affected both in battle conditions and in daily military activities. It is acknowledged throughout the world that late effects for people who suffered from the acute CO intoxication can develop different stable variations of the nervous system functioning. The problem of late effects of encephalopathy prevention after acute intoxications with carbon oxide remains unresolved. There is a proven fact that a true highly efficient antidote for intoxications with carbon oxide is oxygen. There is still being performed a search of a possibility to apply solutions with enhanced concentration of ox-ygen in normal conditions for prevention and treatment of acute intoxications with carbon oxide. As a result, there arises a question of efficiency of applying solutions of another form of oxygen for the same purpose – ozone. In our work, there was conducted an experimental evaluation of late effects of peroral application of ozonized physiological solutions for prevention of memory and learning disorders in rats after an acute intoxication with carbon oxide. The results were supported with a morphological investigation of the rats’ brain.

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