The estimation of biological activity of novel derivatives azoles by responses of the erythrocytary system

In the paper, results of the investigation of the five-time intraperitoneal administration of novel azoles derivatives, 1,1-di(1H-imidazol-1-yl)methanimine and 1,1-bis(4-methyl-1H-imidazol-1yl)methanimine jn the red blood cells system parameters (amount of the red blood cells, reticulocytes and hemoglobin in the peripheral blood) are presented. It was found that the administration of 1,1-bis(4-methyl-1H-imidazol-1yl)methanimine induced an increase in all parameters studied, whereas administration of the 1,1-di(1H-imidazol-1-yl)methanimine caused an increase only in amount of reticulocytes. Possible mechanisms of action of the compounds are discussed.

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