Vascular-thrombocytic part of hemostasis in the long-term postoperative period in children underwent spleen surgeries

Study goal: to study correlation between the surgery performed due to spleen injury in children and the changes in vascular-thrombocytic part of hemostasis in the long-term postoperative period. Material and methods. Platelet aggregation activity and their carbohydrate composition were studied in 56 children underwent surgeries on damaged spleen during more than one year. Platelets aggregation activity and their carbohydrate composition were studied in 56 children underwent surgeries on damaged spleen during more than 1 year. Platelets aggregation was studied using a laser aggregation analyzer “Biola 230”. Plant lectins (concanavalin A (Con A), wheat germ lectin (WGA) and phytohemagglutinin P – PHA-P) were used as aggregation inducers for washed platelets. Results. It is shown that splenectomy leads to an increase of platelets aggregation activity in the longterm postoperative period due glycoprotein b-D-galactose, N-acetyl-D-glucosamine and N-acetyl-neuraminic (sialic) acid receptors. Herewith, glycoprotein receptors containing b-D-galactose are more important. Autolientransplantation partially prevents changes in platelets aggregation activity in the long-term postoperative
period. An increase of platelets aggregation activity after autolientransplantation is associated with mannose receptors. In 42,8 % of cases, the changes of platelet aggregation after splenectomy result in the complications.

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