The article presents a study which aims to determine the prognosis of wound healing using the integral hematologic indexes. The study was devoted to the assessment of the integral hematologic indexes in rats with wounds to predict the outcome of the wound process. The study included 297 albino male rats weighing 190–210 g. The rats were divided into 3 groups (99 rats in each): control group, rats with a modelled wound process and abdominal wall tension, and rats with a modelled wound process with the use of transplant. During the experiment we estimated the following integral hematologic indexes: Krebs index, Bredeck index, leukocyte index, neutrophils/monocytes ratio, lymphocytes/monocytes ratio, lymphocytes/eosinophils ratio, albumin/globulin ratio, oxyproline coefficient. Our results suggest that changes in integral hematologic indexes in rats were mostly statistically and clinically significant. Thus, we can conclude that pathophysiological features of the blood reactions under various conditions (modelling of wound healing) are crucial in both specific and non-specific protective reaction of the organism affecting its resistance and reactivity and, therefore, determining the course and the outcome of wound healing.