All Posts in Category: Medical Herald №023-2016

The morphology of the wound healing process (literature review)

Wound healing process – a complex set of local and general reactions of the organism, developing in response to tissue damage and the introduction of infection. It is the most common types of pathophysiological processes, combining deep physical and chemical changes in the organs and tissues with severe clinical manifestations, significantly affecting the quality of life of the patient. Despite the fact that this process is the subject of many scientific studies, to date, there is no unity of medical-diagnostic tactics, and are not designed for hiking universal flow forecasting wounds. Studying the dynamics of wound healing process is of fundamental and practical importance. Only by having an accurate idea of the function of each of the cells involved in the wound healing process, it is possible to develop rational, objective, pathogenetically based treatment of wounds and prevent a wide range of complications. The unity of the understanding of psychophysiological and molecular changes in patients with different localization of wounds can clarify the understanding of the prognosis of the wound healing process. When analyzing the data of literature formed a certain impression about the advantages and disadvantages of different methods and it is possible to assess their prospects. Given the importance of the problem and its unresolved in respect of etiology and pathogenesis, as well as the individual characteristics of the mechanisms of wound healing process, we focused on the historical perspective of views on the wound process.

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Kisspeptin – new control of reproduction: physiological aspects

This article describes the physiological role of a recently discovered neuropeptide – kisspeptin, playing a key role in the regulation of reproductive function in humans and mammals. The features of structural and functional organization of kisspeptin system are discussed, as well as the impact of physiological aspects of activity of the suprachiasmatic nucleus neurons on it in the invitro studies.

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Acute toxicity and articaine d-s forte cumulation in different ways of administration

The paper presents results of a study of acute toxicity and cumulative properties of articaine at different routes of administration in mice. The experiment found that the maximum tolerated dose of articaine D-S Forte for mice with intraperitoneal administration is 240mg / kg, LD16 = 253.24; average lethal dose LD50 = 266,67 ± 2,76, absolutely lethal dose – 290mg / kg, and the coefficient of cumulation is Cc = 5.48. The maximum tolerated dose when administered intramuscularly for mice is 150 mg / kg LD16 = 203 mg /kg LD50 = 255 ± 21,71mg / kg and LD100 – 400mg / kg.

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Features of life and medical activity of intensivists

The article presents data of questionnaire of intensivists, other physicians (internists), middle and junior medical staff of multidisciplinary hospital. Our findings revealed a number of features, some of them linked to incidence of such bad habits as smoking and the alcohol abuse, the others – with food and physical activity. It is shown that on the basis of personal assessment the food habits of intensivists do not correspond to the principles of a healthy diet, recommended by the World Health Organization and physical activities are related to household activities and work in their spare time in the garden area, while recreational exercises and tempering of the body are regularly performed only by a small part of the doctors. The article also assessed the medical activities of physicians compared to nurses working in intensive care units of general hospital, and shows that indicators of physical operational readiness of doctors are worse than of nurses of intensive care units.

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Public healthcare: study of the hierarchical interaction of the concerned sectors

Objective: To study the hierarchical interaction of sectors interested in the healthcare of population. Materials and methods. Anonymous survey among healthcare organizers. Results. The comparative assessment of the linkages between the sectors interested in the healthcare of population was held. Conclusion. These results complement the understanding of the functioning of system of inter-sectoral cooperation in public health and can be useful in proving the directions of its optimization.

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Availability of medical laboratory tests for doctors of the samara region

This paper provides information about the availability of referral to the laboratory tests for different groups of doctors of the Samara Region. The work took into account the opinion of practitioners with higher medical education. It was found that the prevailing group of doctors, regardless of age, sex, qualification category, professional experience, has insignificant restrictions (low availability for some rare tests only). The difference is observed for doctors with different geography of work: doctors in rural areas have more obstacles than the doctors from the cities. It is revealed that doctors who use laboratory studies in their practice most have practically no limitations in the laboratory tests, or they are few in number, whereas other groups of doctors have a similar picture of the limitation in the appointment of tests.

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The issue of national cultural and religious preferences of the production and use of medicines

The article raises the question of the relationship between the source of origin of the feedstock for the production of medicines and preferences or restrictions in patients in their application based on their ethnocultural and religious traditions. This is a relatively independent, relevant and practically important topic for consideration in the framework of social pharmacy, studying medicines in a broader perspective (political, ethical, social, etc. aspects). In accordance with this approach, as well as in the context of the implementation of the “Agreement on Cooperation between the Ministry of Health of Russia and Russian Orthodox Church” the Federal Law “On biomedical cell products” was discussed. Based on the review of the Law and the “Social Concept of the Russian Orthodox Church” the conclusion was made about the moral acceptability of the Orthodox consciousness of biomedical cellular products usage, the raw material for which are the cells, tissues and organs taken from living and dead people (donors).

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Influence of glycolic acid on microcirculation of blood in the skin at age-related changes

The article presents the results of studies of the effect of glycolic acid on blood circulation in the skin
with age-related changes. It was found that the skin of the hands of men and women aged 30–60 years compared to people aged 20–30 years showed a reduction in the microcirculation index by an average of 18 %  and a decrease in oxygen saturation of mixed blood by an average of 25%. After exposure of glycolic acid
solutions of different concentrations the following changes are displayed: improving microcirculation indicator by average 23 % (36 % solution) and 26 % (50 % solution), an increase in oxygen saturation of mixed
blood by 20 % (36 % solution) and 22 % (50 % solution) in comparison with the values prior to exposure.
Application of therapy aimed at correcting of blood microcirculation disorder is justified in patients of different age groups, including with the presence of pronounced wrinkles and other signs of aging.

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Geriatric syndromes in palliative practice: analysis of issue in age aspect

The article presents the age analysis of geriatric syndromes, allowing to create a profile of integral medical, psychological and social problems in the provision of palliative care. It is shown that the medical problems were more common in the elderly stroke, p < 0.05. Among the psychological problems the lack of communication, conflicts in the family because of illness, fear and anxiety dominated. These concerns were also expressed in the elderly with cerebrovascular disease, which was accompanied by social problems (lack of communication, lack of family involvement in the lives of older people, lack of medicaments (p < 0.05).

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