Wound healing process – a complex set of local and general reactions of the organism, developing in response to tissue damage and the introduction of infection. It is the most common types of pathophysiological processes, combining deep physical and chemical changes in the organs and tissues with severe clinical manifestations, significantly affecting the quality of life of the patient. Despite the fact that this process is the subject of many scientific studies, to date, there is no unity of medical-diagnostic tactics, and are not designed for hiking universal flow forecasting wounds. Studying the dynamics of wound healing process is of fundamental and practical importance. Only by having an accurate idea of the function of each of the cells involved in the wound healing process, it is possible to develop rational, objective, pathogenetically based treatment of wounds and prevent a wide range of complications. The unity of the understanding of psychophysiological and molecular changes in patients with different localization of wounds can clarify the understanding of the prognosis of the wound healing process. When analyzing the data of literature formed a certain impression about the advantages and disadvantages of different methods and it is possible to assess their prospects. Given the importance of the problem and its unresolved in respect of etiology and pathogenesis, as well as the individual characteristics of the mechanisms of wound healing process, we focused on the historical perspective of views on the wound process.