The morphology of the wound healing process (literature review)

Full article

Wound healing process – a complex set of local and general reactions of the organism, developing in response to tissue damage and the introduction of infection. It is the most common types of pathophysiological processes, combining deep physical and chemical changes in the organs and tissues with severe clinical manifestations, significantly affecting the quality of life of the patient. Despite the fact that this process is the subject of many scientific studies, to date, there is no unity of medical-diagnostic tactics, and are not designed for hiking universal flow forecasting wounds. Studying the dynamics of wound healing process is of fundamental and practical importance. Only by having an accurate idea of the function of each of the cells involved in the wound healing process, it is possible to develop rational, objective, pathogenetically based treatment of wounds and prevent a wide range of complications. The unity of the understanding of psychophysiological and molecular changes in patients with different localization of wounds can clarify the understanding of the prognosis of the wound healing process. When analyzing the data of literature formed a certain impression about the advantages and disadvantages of different methods and it is possible to assess their prospects. Given the importance of the problem and its unresolved in respect of etiology and pathogenesis, as well as the individual characteristics of the mechanisms of wound healing process, we focused on the historical perspective of views on the wound process.

Bibliography:
  1. Dmitriev A.E., Krjukov B.N. Method of prevention of complications by early diagnosis of bacterial contamination of surgical wounds. Prevention of complications in surgery. Collection of scientific works. Moscow: 1983; 26-28.
  2. Majanskij D.N. Chronic inflammation of the. Medicine, Moscow: 1991; 272.
  3. Garkavi A.B., Eliseev A.T. Wounds and wound infection, its prevention and treatment. Medical care. 2000; (5). 3-7.
  4. Lucevich O.Je., Tolstyh P.I., Tamrazova O.B., Pleshkov A.S., Vorotilov Ju.V., Ismailov G.I., Shikunova A.Ju. Amodern view of the pathophysiology and treatment of purulent wounds. Surgery. 2011; (5). 72-77.
  5. Rackallio, J. Enzyme histochemistry of wound healing. Stuttgart: Portland (USA): Fischer, 1970. – P. 270.
  6. Kuzin M.I., Kostjuchenok B.M. Objective evaluation criteria of the wound process. In the book. “Wounds and wound infection”. Moscow: 1990; р.190.
  7. Al’pern D.E. Inflammation (pathogenesis). Moscow: Medgiz; 1959; p. 286.
  8. Belokrickij D.V., Kudrjashova I.I., Smirnov N.G., Smirnova V.M. The role of certain factors of nonspecific resistance in the emergence of postoperative purulent complications. Prevention of complications in surgery. Collection of scientific works. Moscow: 1983; 7-9.
  9. Aliev A.A., Mamedov H.P., Medzhidov F.A., Kerimov R.B., Allazov V.I. The effectiveness of hydrogen peroxide for the prevention of postoperative wound suppuration. Surgery. 1989; (7). 61-62.
  10. Shimkevich L.L. Histochemical study of the connective tissue in the focus of aseptic inflammation. Abstract. dis. …k. med. sciences. Moscow: 1965; 20 с.
  11. Mirskij M.B Surgery from antiquity to the present (studies in the history). Science, Moscow: 2000; 798.
  12. Mamedov L.A., Gusejnov L.M. A new method for the diagnosis of purulent-inflammatory complications of postoperative wounds. Wound and wound infection. The book of abstracts. Andijan.1995; 28.
  13. Abo Т., Kawamura Т., Watanabe Н. Physiological responses of extrathymic T cells in liver // Immunol. Rev. 2000. Vol. l74. P. l35–149.
  14. Kamaev M.F. Infected wound and its treatment. Medicine, Moscow: 1970; 159.
  15. Anisimov V.N., Popovich I.G., Zabezhinski M.A., Egormin P.A., Yurova M.N., Semenchenko A.V., Tyndyk M.L., Panchenko A.V., Trashkov A.P., Vasiliev A.G., Khaitsev N.V. Sex differences in aging, life span and spontaneous tumorigenesis in 129/sv mice neonatally exposed to metformin. CellCycle. 2015; 14 (I, 1): 46–55.
  16. Broughton G., Janis JE, Attinger CE. The basic science of wound healing // Plast. Reconstr. Surg. 2006. Vol. 117.No 7. Suppl. P. 12S–34S.
  17. Gudynskaja C.Ja., Deputovich S.A. Prevention of thromboembolic complications in patients with obliterating endarteritis. Prevention of complications in surgery. Collection of scientific works. Moscow: 1983; 16-19.
  18. Nikolaev N.E. The value of this method of suturing the surgical wound to prevent wound complications. Surgery, 1984; (6) 7-9.
  19. Ross R. Wound healing. In the book: Molecules and cells. The world, Moscow: 1970; (5). 134-152. (in Russian)
  20. Sluckij L.I. Biochemistry of normal and pathologically changed connective tissue. Medicine, Leningrad:1969; 374.
About the authors

  • A.A. Devyatkin
  • Samara Medical Institute «REAVIZ» 443001, Samara, st. Chapaevskaya, 227 doctor of medical science professor of public health and health care, e-mail: mail@reaviz.ru

  • A.A. Supilnikov
  • Medical university «Reaviz», 443001, Samara, st. Chapaevskaya, 227, candidate of medical science, associate professor, vicerector for research activities, head of department of morphology and pathology

  • O.N. Gulenko
  • Medical university «Reaviz», 443001, Samara, st. Chapaevskaya, 227, candidate of biological sciences, Specialist publishing department

  • O.N. Pavlova,
  • Samara Medical Institute «REAVIZ», 443001, Samara, st. Chapaevskaya, 227, candidate of biological sciences, assistant professor of natural sciences, e-mail: casiopeya13@mail.ru